Common name lidocaine English name Lidocaine
CAS number 137-58-6 molecular weight 234.337
density 1.0±0.1 g/cm3 boiling point 372.7±52.0 °C at 760 mmHg
molecular formula C14H22N2O melting point 66-69°C
Lidocaine is a histamine H1 receptor inverse agonist with IC50>32 μM.
Lidocaine is a local anesthetic, also known as sirocaine, which has replaced procaine in recent years and is widely used in cosmetic plastic surgery for local infiltration anesthesia, which blocks nerve excitation and conduction by inhibiting the sodium ion channel of the nerve cell membrane. Its fat solubility and protein binding rate are higher than that of procaine, and it has strong ability to penetrate cells, has a fast onset of action, a long time of action, and a strength of action that is 4 times that of procaine.
It is clinically used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including mucosal anesthesia during thoracoscopy or abdominal surgery) and nerve block. In order to prolong the duration of anesthesia and reduce side effects such as lidocaine poisoning, epinephrine can be added to the anesthetic.
Whatsapp/ +86 15355326496
Telegram/ @rosechem2024
Signal/ +86 13071223997
Threema/ TY75RJSS
Email/
[email protected]Element/ @haitpharm:matrix.org
Session/ 0551995ec783ba06cf3384aa286dfe81244487ef630a59a40f547bb177a30cbd68